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From a process chemist point of view, developing an enzymatic process at industrial scale, is very much the same challenges and principles than any other chemical processes strategies. The exception relies however in understanding the behaviour of the biocatalyst for optimal performance and robustness. In this article, we wish to review the key stages that are required for implementing a biocatalytic process at industrial scale, supported by 4 case studies.

Seqens has developed a unique FOS composition, made from sucrose and presenting a large diversity in chain length. While short chains are metabolized quickly by colonic bacteria, medium chains have a sustained effect over time and very long chains are likely to be excreted before being fully metabolized by the bacteria.  Our unique FOS composition corresponds to an optimal balance between short and medium chain lengths. 

Enzyme evolution involves some changes of amino acid residues that constitute the sequence of the protein, which can alter its conformational dynamics and ultimately affect its enzymatic function