Knowledge Center

High Throughput Experimentation (HTE) has emerged as an important tool to assist and accelerate the productivity of the synthetic chemist. This iterative process of design, execution, data analysis, and hit identification enables rapid exploration of conditions for reaction discovery and optimization. In this article, we highlight the powerful use of HTE within the fields of multi-catalysis and new route synthesis, with a particular focus on late-stage functionalization.

Watch this webinar presented by Seqens team of experts to understand how you can benefit from early solid form screening and related activities.

Watch this webinar where our experts will present detailed case studies on the development of a continuous process to an API and on the development of safe processes to key pharmaceutical intermediates or specialty ingredients.

Watch this webinar where SEQENS will present how to help solving the specific manufacturing challenges associated with the New Molecular Entities in development in oncology.

In this article, we wish to highlight some recent developments for implementing more sustainable processes in the field of photochemistry, flow chemistry, and biocatalysis. Smarter process is also about process intensification and combining technologies, such as flow chemistry with photochemistry or biocatalysis.

We asked 9 questions to Dr. Julien Leroudier, our technical expert in solid state characterization and scalable crystallization process about solid form.

Over the past decade, a profound shift has been underway in the pharmaceutical industry, as continuous flow processes gain momentum alongside traditional batch methods. This transformation is propelled by advancements in flow reactor technology, promising enhanced efficiency, safety, and sustainability in chemical production. In this article, we delve into the transformative power of flow chemistry, exploring its myriad benefits and applications in fine chemicals and active pharmaceutical ingredient (API) manufacturing.

Seqens has developed a unique FOS composition, made from sucrose and presenting a large diversity in chain length. While short chains are metabolized quickly by colonic bacteria, medium chains have a sustained effect over time and very long chains are likely to be excreted before being fully metabolized by the bacteria.  Our unique FOS composition corresponds to an optimal balance between short and medium chain lengths. 

We asked 5 questions to Dr. Sonia Lombardo, Preformulation Solid State Engineer at SEQENS, about bioavailability improvement and pre-formulation studies during drug development.

Facing a highly competitive global market with increasing awareness on environmental issues, chemical production is making its way toward a paradigm shift to more efficient, more environmentally friendly, and more versatile manufacturing processes. In this white paper, we wish to review some of the key advanced tools available to process chemists for addressing the challenges in process intensification.

The access to a novel variety of 4-fluorinated isoxazoles bearing an aryl or alkyl group at the C-3 position and an acetal fragment at the C-5 position has been achieved through a direct fluorination using N-fluorobenzenesulfonimide (NFSI) with yields up to 75%. This method was transposed to gram-scale and has been applied to the formal synthesis of a bioactive compound that increases CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity.

During this webinar, we present the specific challenges encountered by Biotech companies when developing New Chemical Entities from Discovery phase to Early Clinical phases. A case study is presented on an API presenting a low water solubility and at the same time a low solubility in lipophilic solvents.

Discover in the latest Organic Letters issue, how SEQENS in collaboration with Géraldine Masson, have developed a more greener approach for the decarboxylative borylation, leading efficiently to a- and b-amino-boronamides, an important class of compounds in medicinal chemistry.

This paper presents the different strategies considered to enhance pharmaceutical drugs bioavailability.
A special focus is made on the need
to understand, at early stage, the behaviour and the characteristics of these compounds, especially physical, chemical and biological
properties.

Highly potent drugs represent a growing proportion of medicines, including therapies in development and those commercially available. In this article, discover some best practices and synthetic route considerations for delivering highly potent drugs.

The concept of multi-catalysis is an emerging field targeting the development of new efficient catalytic systems combining multi-step synthesis in new ‘one-pot’ transformations or in multi-catalytic sequences.

Nitrosamines are a group of organic compounds containing the nitroso functional group. In this white paper, we review the main analytical techniques that have been investigated, and then we will present our work regarding the development of a UPLC-HRMS technique for identifying and quantifying Nitroso Drug Substances Related Impurities, at ppb level in APIs.

About 30% of all APIs carry a Fluor atom, and many APIs need at least one fluorinated intermediate during their synthesis. Using continuous flow chemistry for fluorination steps could improve reactions performances in terms of reaction time and conversion ratio.

Enzyme evolution involves some changes of amino acid residues that constitute the sequence of the protein, which can alter its conformational dynamics and ultimately affect its enzymatic function

Seqens participated to this year’s annual meeting of the American Society of Clinical Oncology (ASCO), held in Chicago on June 2-6 .

A proof-of-concept study for the synthesis of 1,2-difluorobenzene from 2-fluoroaniline via the Balz−Schiemann reaction using HF/pyridine as the fluorinating reagent is reported. Key to success for a fast reaction, a clean reaction profile - and thus high product selectivity - was a photochemically induced fluorodediazoniation of the in situ-generated diazonium salt performed in a continuous flow mode.