Protéus - SEQENS

Microorganisms, Enzymes & Industrial Biocatalysis

Biosolutions by design

Protéus

Our platform offers innovative technologies and 25+ years of expertise in microbiology, protein engineering and scaling-up biocatalytic processes for sustainable manufacturing & renewable products.

Co-development Partnerships / One-off Services / Proprietary Products

Application Market

PHARMA APIs SYNTHESIS

SEQENZYM VL API multi-tons biosynthesis on Seqens manufacturing site

Enzyme production scale-up from 40L to 300L
Biocatalyst loading 0.2%
Enzyme cost/kg product is below <5%
High specificity ee >99.9%
High productivity 200g/L
High level of reproducibility

PHARMA APIs SYNTHESIS

SEQENZYM® AL D-Serine multi-tons biosynthesis on Seqens manufacturing site

Enzyme production scale-up from 300L to 15m3
High specificity ee >99.9%
High substrate concentration >30%
Enzyme cost/kg product is below <5%

FOOD & FEED

SEQENZYM® FT Bioconversion of sucrose into short-chain Fructo-Oligosaccharides (FOS) Benefits of SEQENZYM® FT

Independant from sugar source
Highest yield > 60% Total FOS
Higher purification yields
Lowest free Fructose < 1%
No color formation < 10 ICUMSA

COSMETICS

Biocatalytic route to Estolides a high naturality process for a plant-based ingredient

Biosourced substrates from castor oil (non food crop)
Biosynthetic process advantages: Low temperature; No color; Lower energy consumption; No metal catalyst
Variable properties: Solid, Liquid, Semi-solid; Emulsion, depends on capping agents; Prolonged release; Well tolerated; GRAS: Oral and topical administration
Cosmetic applications: Skin hydration, Natural antioxydant, Hair additive, Texturizing

FLAVOR & FRAGRANCE

(-)-Ambrox biosynthesis Squalene hopene cyclase optimization

1x round of directed evolution
Optimization of the reaction conditions by DoE for the best performing variant
Factor 10x productivity improvement
Conversion obtained with 125g/L of substrate with the best variant

>> Click to read the corresponding publication

« Biocatalytic Process for (−)-Ambrox Production Using Squalene Hopene Cyclase ». Source: Advanced Synthesis & Catalysis 360, no 12 (15 juin 2018): 2339‑51

FLAVOR & FRAGRANCE

Green Notes biosynthesis Optimization of a 13-HPL from guava puree

4x round of directed evolution with homologous enzymes
65,000 variants screened
Factor 15x activity improvement
Factor 48x thermostability improvement

AGROSCIENCES

Biocontrol Toxin Discovery Collaborative Project DIETETIC

Identification of insecticidal activities against corn rootworm larvae (Diabrotica virgifera virgifera) from Protéus microbial diversity
1’300 strains screened
Co-development opportunities

AGROSCIENCE

SEQENZYM βG Biogas production booster Speeds up time to maximum methanization Increase methanogen potential Characteristics:

Fungi cell culture supernatant (liquid form)
Cocktail of cellulases & hemicellulases
Optimized to degrade cellulosic biomass:

β-glucosidase activity enhanced 240x (on model substrates)

Stimulates the breakdown of long-chain, water-swelling polysaccharides (mucilage) into short-chain, water-soluble sugars

SEQENZYM BioHub

Protéus document center

SEQENZYM Kit

Discover SEQENZYM Customized Kits for Enzyme hit detection. >> Click and download the SEQENZYM Customized Kits

SEQENZYM FT

SEQENZYM FT is a new enzymatic product to convert saccharose into short-chain Fructo-Oligosaccharides (scFOS) >> Click and download the SEQENZYM FT

SEQENBIOTICS Nutra

Explore our microbial collection from exotic ecosystems
Expand possibilities within biodiversity with our microbiology services

>> Click and download the SEQENBIOTICS Nutra

Certifications & partnerships

At Protéus by Seqens, we believe in the power of collaboration and continuous learning. As part of our commitment to excellence, we actively engage with scientific associations, industry clusters, and certification bodies.

Discover other R&D services

Alganelle

An innovative Biotech company with 30 years of experience and 4 patents at the edge of Synthetic Biology and Metabolic engineering to optimize various microorganisms.

Learn more

Aramon’Lab

The Aramon laboratory, in France, is specialized in the development of polymers for the controlled release of active pharmaceutical ingredients.

Learn more

Boston'Lab

Boston’Lab

Our Boston’Lab in the US has deep experience in helping our clients in their early phase project.

Learn more

Middles- brough’Lab

Middlesbrough’Lab

The R&D laboratory at Middlesbrough (UK) offers a wide range of equipment for fine chem and cosmetics developments.

Learn more

Pune’Lab

Pune'Lab

The Pune laboratory in India is SEQENS center of excellence for the development of new generic APIs

Learn more

Seqens’Lab

Seqens’Lab, located in France near Paris, offers a unique ecosystem dedicated to our customers to accelerate their projects from discovery to production and sales.

Learn more