Decatungstate-Photocatalyzed Diastereoselective Dearomative Hydroalkylation of Indoles
26/09/2024
Publication
By
- Emeric Montinho-Inacio
- Damien Bouchet
- Wei-Yang Ma
- Pascal Retailleau
- Luc Neuville
- Géraldine Masson
In this study, we present an efficient and straightforward dearomative hydroalkylation of indoles. By utilizing alkanes or ethers as alkyl radical sources and employing TBADT as a costeffective photocatalyst for direct hydrogen atom transfers (HAT), we achieved successful conversion of these heterocyclic derivatives into 2-alkylindolines with good to excellent yields and high diastereoselectivity under mild reaction conditions.
