Draft Genome Sequence of Lactobacillus crispatus CIP 104459,Isolated from a Vaginal Swab
By Maximilien Clabaut
Amine M. Boukerb
Pierre-Jean Racine
Chantal Pichon
Coralie Kremser
Jean-Pierre Picot
Madina Karsybayeva
Gérard Redziniak
Sylvie Chevalier
Marc G. J. Feuilloley
We report the draft genome sequence of Lactobacillus crispatus CIP 104459, isolated from a human vaginal swab. This draft genome consists of 1,993,673 bp, with 36.8% G C content and 2,024 predicted protein-encoding sequences.
Lactobacilli are the predominant vaginal microbiota found in healthy women of reproductive age. Several studies have revealed that vaginal disorders and dysbiosis are closely related to lactobacillus decrease and pathogen increase (1). Lactobacillus crispatus is one of the dominant species in the normal vaginal environment and plays an important role in preventing infections such as bacterial vaginosis (BV) and in modulating inflammation (2). L. crispatus is a producer of lactic acid, hydrogen peroxide, and other antimicrobial compounds that inhibit the growth (3), hyphae, and biofilm formation of Candida albicans (4) and reduce the cytotoxicity of Gardnerella vaginalis (5) and the infectivity of Chlamydia trachomatis (6). L. crispatus seems to possess additional protective mechanisms against BV and contributes to the maintenance of the normal vaginal microbiota (2)
