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Enantioselective Reduction of Cyclobutenones Using Ene-Reductases

14/08/2024
Publication

By Tomohiro Yasukawa, Project assistant professor – The University of Tokyo
Pierre Gilles, Innovation Project Manager – Bioservices
Juliette Martin, Scientific Communication Manager
Julien Boutet, Head of Innovation – Innovation
Janine Cossy, Professor Emeritus

Chiral cyclobutanes are important structural features that are widely present in many biologically active natural and non-natural products. The threedimensional structure of cyclobutanes opens opportunities for applications in medicinal chemistry, and the introduction of this structural motif in smallmolecule drug candidates has been increasing in recent years.

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Expertise / White paper
Unlocking the Potential of Flow Chemistry to Transform Pharmaceutical Manufacturing Processes

Over the past decade, a profound shift has been underway in the pharmaceutical industry, as continuous flow processes gain momentum alongside traditional batch methods. This transformation is propelled by advancements in flow reactor technology, promising enhanced efficiency, safety, and sustainability in chemical production. In this article, we delve into the transformative power of flow chemistry, exploring its myriad benefits and applications in fine chemicals and active pharmaceutical ingredient (API) manufacturing.