Knowledge Center

We asked 5 questions to Dr. Sonia Lombardo, Preformulation Solid State Engineer at SEQENS, about bioavailability improvement and pre-formulation studies during drug development.

Peptides in the era of biotech.

Watch this webinar where SEQENS and GenEvolutioN will present how to cope with the new Nitrosamines regulations for the development of Drug Substances and Drug Products.

Facing a highly competitive global market with increasing awareness on environmental issues, chemical production is making its way toward a paradigm shift to more efficient, more environmentally friendly, and more versatile manufacturing processes. In this white paper, we wish to review some of the key advanced tools available to process chemists for addressing the challenges in process intensification.

During this webinar, we present the specific challenges encountered by Biotech companies when developing New Chemical Entities from Discovery phase to Early Clinical phases. A case study is presented on an API presenting a low water solubility and at the same time a low solubility in lipophilic solvents.

Discover in the latest Organic Letters issue, how SEQENS in collaboration with Géraldine Masson, have developed a more greener approach for the decarboxylative borylation, leading efficiently to a- and b-amino-boronamides, an important class of compounds in medicinal chemistry.

This paper presents the different strategies considered to enhance pharmaceutical drugs bioavailability.
A special focus is made on the need
to understand, at early stage, the behaviour and the characteristics of these compounds, especially physical, chemical and biological
properties.

Highly potent drugs represent a growing proportion of medicines, including therapies in development and those commercially available. In this article, discover some best practices and synthetic route considerations for delivering highly potent drugs.

The concept of multi-catalysis is an emerging field targeting the development of new efficient catalytic systems combining multi-step synthesis in new ‘one-pot’ transformations or in multi-catalytic sequences.

Seqens Personal Care Article

About 30% of all APIs carry a Fluor atom, and many APIs need at least one fluorinated intermediate during their synthesis. Using continuous flow chemistry for fluorination steps could improve reactions performances in terms of reaction time and conversion ratio.

Enzyme evolution involves some changes of amino acid residues that constitute the sequence of the protein, which can alter its conformational dynamics and ultimately affect its enzymatic function

Seqens participated to this year’s annual meeting of the American Society of Clinical Oncology (ASCO), held in Chicago on June 2-6 .